THE EFFECT OF SEVOFLURANE AND PROPOFOL ON HEMODYNAMICS WHEN BIS IS 50

Objective To observe the changes of hemodynamics during three different methods of anesthesia when BIS was 50±5. Methods Sixty ASAⅠorⅡpatients scheduled for upper abdominal surgery under general anesthesia were equally randomized to three groups: group S,anesthesia with sevoflurane;group P,with propofol;group C,with sevoflurane+TCI propofol(1 mg/L).BIS was kept at 50±5 at surgery,the fluctuation of heart rate(HR) and systolic blood pressure(SBP) would not exceed 30% of the baseline.Hemodynamic parameters,BIS were recorded at different time points from anesthesia induction till completion of operations research. Results BIS and SBP were significantly decreased after anesthesia induction in three groups,but the changes of HR were not significant.At tracheal intubation,HR and SBP increased in the three groups,which were higher in groups P and S than group C(P0.05).At exploration,the rising of HR and SBP in groups P and S was more obvious than that in group C(P0.05). Conclusion When anesthesia with sevoflurane+TCI propofol(1 mg/L),maintaining BIS between 50±5,the fluctuation of hemodynamic parameter would be more stable.