Lipid storage myopathy:report of a case and review of literature

Objective To analyze the clinical and pathological features of lipid storage myopathy(LSM).Methods The clinical data,laboratory results and muscle biopsies of a case of LSM were analyzed and having the related literature reviewed.Results Weakness of proximal limb muscles and intolerance to exercise were the prominent clinical manifestations.Serum muscle enzymes were moderately elevated,and electromyogram(EMG) showed myogenic damages.Myopathological changes included vacuole degeneration of muscle fiber and increase of lipid droplets.Conclusions LSM is a rarely seen myopathy.Weakness of proximal limb muscles and intolerance to exercise are the two major clinical manifestations.The definite diagnosis depends on the muscle biopsy,and the prognosis is relatively well.