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2008•Chinese Journal of MisdiagnosticsRequires access

Clinical and Pathological Features of Lipid Storage Myopathy:Two Cases Report and Literature Review

Wei-guo Sun

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Abstract

Objective:To investigate the clinical and pathological features of Lipid storage myopathy(LSM).Methods:The clinical data and laboratory results of 2 cases were collected,muscle biopsies were done with routine and histochemical staining.Results:Weakness of the proximal limb muscles and fatigue were the prominent clinical manifestations.In mort of cases,atrophy was not significant,serum muscle enzymes were slightly or moderately elevated,and EMG presented myogenic features.Myopatholoical changes showed many vacuoles in the muscle fibers,Electron microscopic observation demonstrated excessive accumulation of lipid droplets.Conclusion:LSM is a rare myopathy.Weakness of the proximal limb muscles and fatigue are the prominent clinical manifestations.It is often misdiagnosed for long time.The definite diagnosis of this disease dependes on the muscle biopsy.

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What this paper is about

Objective:To investigate the clinical and pathological features of Lipid storage myopathy(LSM).Methods:The clinical data and laboratory results of 2 cases were collected,muscle biopsies were done with routine and histochemical staining.Results:Weakness of the proximal limb muscles and fatigue were the prominent clinical manifestations.In mort of cases,atrophy was not significant,serum muscle enzymes were slightly or moderately elevated,and EMG presented myogenic features.Myopatholoical changes showed many vacuoles in the muscle fibers,Electron microscopic observation demonstrated excessive accumulation of lipid droplets.Conclusion:LSM is a rare myopathy.Weakness of the proximal limb muscles and fatigue are the prominent clinical manifestations.It is often misdiagnosed for long time.The definite diagnosis of this disease dependes on the muscle biopsy.

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Available abstract

Objective:To investigate the clinical and pathological features of Lipid storage myopathy(LSM).Methods:The clinical data and laboratory results of 2 cases were collected,muscle biopsies were done with routine and histochemical staining.Results:Weakness of the proximal limb muscles and fatigue were the prominent clinical manifestations.In mort of cases,atrophy was not significant,serum muscle enzymes were slightly or moderately elevated,and EMG presented myogenic features.Myopatholoical changes showed many vacuoles in the muscle fibers,Electron microscopic observation demonstrated excessive accumulation of lipid droplets.Conclusion:LSM is a rare myopathy.Weakness of the proximal limb muscles and fatigue are the prominent clinical manifestations.It is often misdiagnosed for long time.The definite diagnosis of this disease dependes on the muscle biopsy.

Key concepts: Medicine, Muscle biopsy, Myopathy, Weakness, Pathological, Atrophy, Pathology, Muscle weakness

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Clinical and Pathological Features of Lipid Storage Myopathy:Two Cases Report and Literature Review — Research Paper | ScholarLens