2011•Unpublished venueRequires access

Expression of Survivin and effect of As_2O_3 on it in bladder cancer cell

Ping Wang

Abstract

Objective:To investigate the effect of As2O3 on Survivin in BIU-87 cell line.Methods:To treat the BIU-87 cells by As2O3 at different concentration,then detect the proliferation activity of BIU-87 by MTT assay,while the expression of Survivin,cell cycle and apoptosis by flow cytometry.Results:After treated with As2O3,the proliferation activity of BIU-87 cells were significantly slowed down compare to the control group,with an evident time and dose-response relationship.As2O3 can induce the apoptosis of BIU-87 cells with concentration dependent.After cultured with As2O3 the expression of Survivin was downregulated significantly,which were concentration dependent.Conclusion:As2O3 can inhibit proliferation activity of BIU-87 cell and reduce the expression of Survivin,induce the apoptosis of BIU-87 cell with concentration dependant.

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Key concepts: Survivin, Apoptosis, Flow cytometry, Cell cycle, Cell growth, Cell, Chemistry, Cancer research