An Analysis of 31 Cases of Renal Biopsy Examination of Children with Refractory Nephrotic Syndrome in Yunnan

Objective:To investigate the type of renal biopsy of children with refractory nephrotic syndrome in Yunnan province.Methods:The renal biopsy reports from 2005 to 2009 of 31 children aged from 5 to 14 with refractory nephrotic syndrome which was primarily developed from glomerular were summarized and analyzed,and all patients,with a course of disease from 5 month as the shortest to 5 years as the longest,had sound results of pathological examination of renal puncture.Results:The pathologic types of the 31 renal biopsy were:diffuse mesangial proliferative glomerulonephritis accounting for 35.5%,focal proliferative glomerulonephritis accounting for 19.4%,focal segmental glomerular sclerosis and hyalinization accounting for 16.1%,IgA nephropathy accounting for 12.9%,IgM nephropathy accounting for 6.5%,mesangial proliferative glomerulonephritis(Ⅱ)accounting for 6.5%,membranous nephropathy(Ⅰ～Ⅱ)accounting for 3.2% respectively.Electron-dense material deposition could be observed with the immunofluorescence examination in all the 31 cases:capillary granular sediment was(+)in 4 cases and(++)in 16 cases,and mesangial clumping deposits was(+ +)in 8 cases and(+ + +)in 3 cases,which prompted that there was heavy damage on renal immune and the prognosis was not desirable.Conclusions:Diffuse mesangial proliferative glomerulonephritis was the main pathologic type,and renal puncture examination is of essential importance in treatment and prognosis of refractory nephrotic syndrome.