Pathological investigation of 20 IgM nephropathy who presented with nephrotic syndrome

Objective:To find out the characteristics of pathology of IgM nephropathy with nephrotic syndrome.Methods: 20 patients with biopsy-proven primary IgM nephropathy who presented with nephrotic syndrome in department of nephrology of our hospital during the period of 2005～2007 were studied.All biopsies were processed for light,immunofluorescence.Results:Renal pathological investigation showed mesangial proliferative glomerulonephritis(MEPGN) in 15 cases(75%),focal and segmental glomerulosclerosis was found in 1 case(5%),membrance glomerulonephritis in 1 case(5%).C3 staining was observed in 25% of specimens with a intensity.Conclusions: Primary IgM nephropathy who presented with nephrotic syndrome is common,the pathology chang is characteristics.