Randomized controlled clinical trial on(+) zopiclone versus zopiclone in the treatment of insomnia

Objective To evaluate the efficacy and safety of (+) zopiclone and zopiclone in treatment of insomnia .Methods A randomized controlled double-blind, double-simulation clinical study was conducted for treatment of patients with insomnia. The dosages were of (+)zopiclone (trial) amd zopiclone (control) 3mg and 7.5mg, respectively ,and all patients have nightly drugs intake,close to bedtime. The duration of treatment was 14 days in both groups. Results Sixty eight insomnia patients were enrolled in trial group, while 57 patients recruited in control group. The results showed that the cure for (+) zopiclonepian and zopiclone based on sleep quality and sleep latency were 20.59% and 14.04 % (P0.05), respectively. While occurrence rate of side effect were 36.76% and 49.12% (P0.05), individually.Conclusion Compared with zopiclone, (+) zopiclonepian is a high efficacy and safety drug for insomnia.