Expression of ILK and PTEN in gastric cancer tissue

[Objective] To research the contribution of ILK and PTEN to the carcinogenesis and development of gastric carcinoma and the relation with anti-oncogene PTEN.[Methods] ILK and PTEN proteins,PTEN mRNA of 76 cases of normal gastric mucosa and 112 cases of gastric carcinoma were detected by immunohistochemistry method and in situ hybridization.[Results] The expression of ILK,PTEN protein in gastric carcinoma group and normal gastric mucosa group,muscular layer invasive group and no muscular layer invasive group,lymphatic metastasis group and non-lymphatic metastasis group were all statistical significance(P0.05 or 0.01),The expression of PTEN mRNA of gastric carcinoma group was lower than that of the normal gastric mucosa group(P0.01).The expression of ILK and PTEN protein had negative correlation(r=-0.347,P0.01).[Conclusion] ILK protein increasing and PTEN protein decreasing have closely relation with the genesis and development of gastric carcinoma,and Controling them may become a new treating target of gastric cancer.