ScholarLens Back to search
2011•Journal of Nanchang UniversityRequires access

Protective Effect of Niacin on Human Umbilical Vein Endothelial Cells Injury Induced by Cholesterol in Vitro

Gao Jiang-yub

Open publisher page 0 citations

Abstract

To investigate protective effect of niacin on human umbilical vein endothelial cells(HUVECs),which injury treated by cholesterol.Use inverted microscope observation cells form,the growth rate of cells was detected by MTT(3-(4,5-dimethylthiazo 1-2-yl)-2,5-diphenylte trazolium bromide) methods.With the increase of cholesterol concentration,the value of MTT was significantly reduced(P0.05).Niacin significantly improved the growth of cells with dose dependent(P0.05).Cholesterol could induce injury for HUVECS,while niacin may prevent HUVECS from the injury.

About this research paper

What this paper is about

To investigate protective effect of niacin on human umbilical vein endothelial cells(HUVECs),which injury treated by cholesterol.Use inverted microscope observation cells form,the growth rate of cells was detected by MTT(3-(4,5-dimethylthiazo 1-2-yl)-2,5-diphenylte trazolium bromide) methods.With the increase of cholesterol concentration,the value of MTT was significantly reduced(P0.05).Niacin significantly improved the growth of cells with dose dependent(P0.05).Cholesterol could induce injury for HUVECS,while niacin may prevent HUVECS from the injury.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

To investigate protective effect of niacin on human umbilical vein endothelial cells(HUVECs),which injury treated by cholesterol.Use inverted microscope observation cells form,the growth rate of cells was detected by MTT(3-(4,5-dimethylthiazo 1-2-yl)-2,5-diphenylte trazolium bromide) methods.With the increase of cholesterol concentration,the value of MTT was significantly reduced(P0.05).Niacin significantly improved the growth of cells with dose dependent(P0.05).Cholesterol could induce injury for HUVECS,while niacin may prevent HUVECS from the injury.

Key concepts: Umbilical vein, Niacin, Cholesterol, In vitro, MTT assay, Chemistry, Pharmacology, Medicine

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Protective Effect of Niacin on Human Umbilical Vein Endothelial Cells Injury Induced by Cholesterol in Vitro — Research Paper | ScholarLens