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2006•Journal of Clinical Internal MedicineRequires access

A Study of the expression of ICAM-1 and P-selectin in human non-small cell lung cancer

Xilin Xu

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Abstract

Objective To investigate the role of ICAM-1 and P-selectin in human non-small cell lung cancer.Methods Immunohistochemical staining method (SP)was used to detect the expression of ICAM-1 and P-selectin in non-small cell lung cancer.Results (1)The positive rate of ICAM-1 and P-selectin expression in lung cancer was significantly higher than those of normal tissue;(2)The expression of ICAM-1 and P-selectin in adenocarcinoma was higher than that of the squamous cell carcinoma,the expression of both in stage Ⅲ+Ⅳ was higher than that of stage Ⅰ+Ⅱ;(3)The positive expression of ICAM-1 in patients with lymph node metastasis was higher than no lymph node metastasis, but P-selectin is not.Conclusions ICAM-1 and P-selectin might be associated with metastasis in lung cancer.

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What this paper is about

Objective To investigate the role of ICAM-1 and P-selectin in human non-small cell lung cancer.Methods Immunohistochemical staining method (SP)was used to detect the expression of ICAM-1 and P-selectin in non-small cell lung cancer.Results (1)The positive rate of ICAM-1 and P-selectin expression in lung cancer was significantly higher than those of normal tissue;(2)The expression of ICAM-1 and P-selectin in adenocarcinoma was higher than that of the squamous cell carcinoma,the expression of both in stage Ⅲ+Ⅳ was higher than that of stage Ⅰ+Ⅱ;(3)The positive expression of ICAM-1 in patients with lymph node metastasis was higher than no lymph node metastasis, but P-selectin is not.Conclusions ICAM-1 and P-selectin might be associated with metastasis in lung cancer.

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Available abstract

Objective To investigate the role of ICAM-1 and P-selectin in human non-small cell lung cancer.Methods Immunohistochemical staining method (SP)was used to detect the expression of ICAM-1 and P-selectin in non-small cell lung cancer.Results (1)The positive rate of ICAM-1 and P-selectin expression in lung cancer was significantly higher than those of normal tissue;(2)The expression of ICAM-1 and P-selectin in adenocarcinoma was higher than that of the squamous cell carcinoma,the expression of both in stage Ⅲ+Ⅳ was higher than that of stage Ⅰ+Ⅱ;(3)The positive expression of ICAM-1 in patients with lymph node metastasis was higher than no lymph node metastasis, but P-selectin is not.Conclusions ICAM-1 and P-selectin might be associated with metastasis in lung cancer.

Key concepts: Medicine, Immunohistochemistry, Lung cancer, Stage (stratigraphy), Adenocarcinoma, Metastasis, ICAM-1, Cancer

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