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2001•Journal of Shanxi Medical College For Continuing EducatlonRequires access

Expression of Apoptosis Related Gene Bcl-2 and Bax in Liver Cell Carcinoma and Its Clinical Significances

Ren Yong

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Abstract

Objective To study the role and the prognostic effect of bcl-2 (an apoptosis suppressing oncogene) and bax(an apoptosis accelerating oncogene)in the development of liver cell carcinoma.Methods Bcl-2 and bax expression was investigated in 40 cases of liver cell carcinoma and 16 cases of normal liver tissue by immunohistochemistry LSAB method.Results The positive rates of bcl-2 and bax expression were 12 5 %and 87 5 % in normal liver tissue and 45 0 %and 52 5 % in liver cell carcinoma.The difference was of significance ( P 0 05).Bcl-2 and bax expression levels were associated with histological grade stages,lymph node metastasis and prognosis.Conclusion The increased expression of bcl-2 and decreased expression bax might be involved in the devetopment of liver cell carcinoma,and they might have a mutual effect on each other.Bcl-2 protein is an independent indicator of prognosis in liver cell carcinoma.

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Objective To study the role and the prognostic effect of bcl-2 (an apoptosis suppressing oncogene) and bax(an apoptosis accelerating oncogene)in the development of liver cell carcinoma.Methods Bcl-2 and bax expression was investigated in 40 cases of liver cell carcinoma and 16 cases of normal liver tissue by immunohistochemistry LSAB method.Results The positive rates of bcl-2 and bax expression were 12 5 %and 87 5 % in normal liver tissue and 45 0 %and 52 5 % in liver cell carcinoma.The difference was of significance ( P 0 05).Bcl-2 and bax expression levels were associated with histological grade stages,lymph node metastasis and prognosis.Conclusion The increased expression of bcl-2 and decreased expression bax might be involved in the devetopment of liver cell carcinoma,and they might have a mutual effect on each other.Bcl-2 protein is an independent indicator of prognosis in liver cell carcinoma.

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Available abstract

Objective To study the role and the prognostic effect of bcl-2 (an apoptosis suppressing oncogene) and bax(an apoptosis accelerating oncogene)in the development of liver cell carcinoma.Methods Bcl-2 and bax expression was investigated in 40 cases of liver cell carcinoma and 16 cases of normal liver tissue by immunohistochemistry LSAB method.Results The positive rates of bcl-2 and bax expression were 12 5 %and 87 5 % in normal liver tissue and 45 0 %and 52 5 % in liver cell carcinoma.The difference was of significance ( P 0 05).Bcl-2 and bax expression levels were associated with histological grade stages,lymph node metastasis and prognosis.Conclusion The increased expression of bcl-2 and decreased expression bax might be involved in the devetopment of liver cell carcinoma,and they might have a mutual effect on each other.Bcl-2 protein is an independent indicator of prognosis in liver cell carcinoma.

Key concepts: Immunohistochemistry, Apoptosis, Oncogene, Carcinoma, Cell, Cancer research, Pathology, Medicine

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Expression of Apoptosis Related Gene Bcl-2 and Bax in Liver Cell Carcinoma and Its Clinical Significances — Research Paper | ScholarLens