Application of Hypertonic Saline of Different Concentrations for Early Liquid Resuscitation in Acute Hemorrhagic Shock Patients

Objective To investigate the application effect of different concentrations of hypertonic saline for early liquid resuscitation in acute hemorrhagic shock patients.Methods 80 cases of acute hemorrhagic shock were equally divided into the treatment group and the control group according to the resuscitation method,40 cases each.All cases were given early liquid resuscitation after surgery,the control group were given the 3.0% sodium chloride + 6% hydroxyethyl starch as the hypertonic saline,and the treatment group were given the 4.5% sodium chloride + 6% hydroxyethyl starch as the hypertonic saline.The plasma interleukin and serum potassium,sodium changes of the two groups were observed and compared before and after treatment.Results All patients were discharged from hospital after emergency treatment,compared to the control group,the plasma IL-1,IL-6 and IL-8 of the treatment group 1 hour after resuscitation were significantly lower(P0.01).Serum potassium of the two groups had no significant difference before and after resuscitatio,but the serum sodium of the control group were increased significantly 1 hour after resuscitation(P0.05),while no obvious change was observed in the treatment group.Conclusion Application of hypertonic saline for early liquid resuscitation in hemorrhagic shock patients can effectively inhibit inflammatory cytokines,and there is no significant adverse changes in body electrolyte,thus is worth of promotion.