Therapeutic effect of hypertonic saline solution on traumatic shock in rats

Objective To evaluate the effect of hypertonic saline solution on traumatic shock resuscitation in rats and explore the possible mechanisms.Methods Rat models of traumatic shock were established in Sprague-Daulay rats,which were randomly divided into two groups: control group and treatment group received 7 5% hypertonic saline to resuscitate. The oxygen partial pressure in the tissues from the skeletal muscles,liver and small intestine were measured at telophase of shock and 1,3 h after treatment.Hydrate volume in lung was detected at 2 h after resuscitation.Meanwhile,the hemodynamics of the rats and their survival rates at 12 adn 24 h were recorded.Results The changes of mean arterial blood pressure and oxygen partial pressure in the liver and small intestine of both groups were statistically significant after resuscitation(P0 05).Hydrate volume in lung at 2 h after resuscitation was significantly lower in the treatment group than in the non-treatment shock group(P0 05),while the survival rates at 12 and 24 h were also significantly different between two groups(P0 05).Conclusion Hypertonic saline resuscitation could improve oxygen partial pressure of internal organs,lighten pulmonary edema and significantly increase the survival rate of rats with traumatic shock.