2004•Zhonghua neifenmi daixie zazhiRequires access

Association of aging with gene OPG, ODF expressions in human osteoblasts in vitro

YU Ming-xiang

Abstract

Human osteoblasts from donors of different age (≤5, 30-40, 50-60, ≥70) groups were isolated and cultured. Osteoprotegerin (OPG) and osteoclast differentiation factor (ODF) mRNA expressions were assayed by RT-PCR when the osteoblasts in the second passage were cultured for 14 days. Results showed that human osteoblasts from different age groups expressed OPG and ODF mRNA. Quantity of OPG mRNA and ODF mRNA expressions was correlated to donor′s age.

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Key concepts: Osteoprotegerin, Internal medicine, Osteoclast, Messenger RNA, Endocrinology, Osteoblast, In vitro, Chemistry