The expression and significance of p53 and BCL-2 proteins in colorectal carcinoma and precancerous lesion

Objective:To explore the relationship between the expression of p53,BCL-2 proteins and the biological behavior of colorectal carcinoma.Methods: Expressions of p53 and Bcl-2 proteins in 20 cases of normal colorectal mucosa,40 samples of colorectal intraepithelial replasia and 90 samples of colorectal adenocarcinoma were detected by immuno-histochemical staining Sp-method.Results: There was no expression of p53 in normal colorectal mucosa.The positive expression rate of p53 in colorectal intraepithelial neplasia was 25%,and in colorectal aderocarcinoma was 62.2%,The rate increased gradually when the grade of intraepithelial neplasia got serious.The positive expression rate of BCL-2 in colorectal carcinoma was 50%,and in intraepithelial neplasia was 47.5%,there was no expression of BCL-2 in normal colorectal mucosa.The expression of BCL-2 was related with the differentiation degree of colorectal carcinoma(P0.05).but was not related with the depth of infiltraction and lymph node metastasis of colorectal adenocarcinoma(P0.05).There was statistical significance between the expression of p53 and lymph node metastasis,but not related with the depth of infiltraction and the differentiation degree.The difference of the 5-years survival rate between the two groups which had positive or negative result in the expression of p53 protein had statistical significance.Conclusion: The expression of p53and BCL-2 was associated with colorectal carcinoma and precancerous lesion,so they might be used as reference factors for the prognosis of colorectal carcinoma.