Clinic study of dexmedetomidine with tramadol to prevent postoperative hyperalgesia induced by remifentanil

Objective To observe the preventive efficacy and safety of dexmedetomidine with tramadol on the patients with postoperative hyperalgesia induced by remifentanil.Methods 70 patients ASA(Ⅰ-Ⅱ)undergoing elective surgery under general anesthesia were randomly assigned into two groups:The patients in group A were given intravenous injection of 1μg·kg-1·h-1 with mini-pump for ten minutes after the intubation,then received intravenous injection of 0.4μg·kg-1·h-1consistently till 30min before the end of the operation,and received intravenous injection of tramadol 1mg·kg-1 before the suturing.The patients in group B were given intravenous injection of the normal saline with the same dose and rate at the same time during the operation,and received intravenous injection of tramadol 1.5mg·kg-1before the suturing.The operation time,recovery time,and the time stay in PACU were recorded.Adverse effects,VAS and Ramsay scores were also recorded.Results Compared with group A,VAS score had no significant difference in group B(P0.05),Ramsay scores was significantly lower in group B early after operation(P0.05),the incidence of patients with postoperative nausea and vomiting,shiver was higher in group B(P0.05).Conclusion Dexmedetomidine combined with tramadol can effectively prevent hyperalgesia after remifentanil anesthesia without significant increase in revival time,and obtain a better sedation.