The clinical analysis of dexmedetomidine combined tramadol for remifentanil- induced hyperalgesia

Objective To investigate the clinical effects of dexmedetomidine combined with tramadol in prevention of remifentanil- induced hyperalgesia. Methods All of patients had general anesthesia in our hospital were divided into observation group and control group randomly,each group was 30 patients. The observation group were given tramadol combined with dexmedetomidine,while the control group were given only tramadol. HR,MAP,scores of degree of sedation at instance and VAS at minutes 20、40、60 after operationwere recorded,and postoperative adverse reaction ratewere observed. Results The HR,MAP and VAS were lower in observation group than that in control group at minutes 40、60 after operation,while the scores of degree of sedation at instance was higher in observation group than that in control group at minutes 40、60 after operation,the difference was statistically significant( P 0.05). The postoperative adverse reaction rate was lower in observation group than that in control group. Conclusion Dexmedetomidine combined with tramadol can effectively prevent remifentanil- induced hyperalgesia,and reduce the occurrence of postoperative complications.