The clinical study of the acute cerebral infarction leading to systemic inflammatory response syndrome which causes multiple organ dysfunction syndrome

Objective To explore the mechanism of the acute cerebral infarction leading to Systemic Inflammatory Response Syndrome(SIRS) which causes Multiple Organ Dysfunction Syndrome(MODS). Methods 68 cases of acute cerebral infarction(ACI) were divided into three groups. 36 cases were acute simple cerebral infarction(SACI group),32 cases were acute cerebral infartion companied with SIRS(SIRS group),24 cases were acute cerebral infarction companied with MODS(MODS group). 28 cases were normal control group. ELISA method was used to measure serum TNF-α and ICAM-1 levels. Results (1)The morbidity of the acute cerebral infarction with SIRS was 47.06%. The morbidity of the acute cerebral infarction with MODS was 35.29%. The morbidity of the MODS was 75.00% when the acute cerebral infarction with SIRS. The morbidity of SIRS was 100% when acute cerebral infarction progressed to MODS. (2)The serum TNF-α and ICAM-1 levels in patients with SACI,SIRS and MODS was significantly different to those in patients of the normal control group(P(0.01)). The serum TNF-α and ICAM-1 levels in patients was MODS group SIRS group ACI group normal control group. The serum TNF-α and ICAM-1 levels in patients with SIRS and MODS was significantly different to those in the patients of SACI group(P(0.01)). The serum TNF-α and ICAM-1 levels in patients with MODS group was significantly different to those in the patients of SIRS group(P(0.01)). The serum TNF-α and ICAM-1 levels in severe patients were higher than in light ones(P(0.01)). The serum TNF-α and ICAM-1 levels in patients with MODS death group were higher than those of survival group. (P(0.01)). Conclusion (1)Acute cerebral infarction might progress SIRS firstly and then progress MODS. (2)The serum TNF-α and ICAM-1 content changing were the possible mechanism in acute cerebral infarction patients with SIRS caused MODS. The level of the serum TNF-α and ICAM-1 content can become the criteria of disease of severe degree and the prognosis in the ACI with SIRS/MODS.