Effect of C-reactive Protein Level on Induced Systemic Inflammatory Response Syndrome in Patients with Acute Senile Cerebral Infarction

Objective To investigate the clinical significance of C-reactive protein(CRP) in identifying systemic inflammatory response syndrome(SIRS) and multiple organ dysfunction syndrome(MODS) induced by senile acute cerebral infarction.Methods A total of 120 patients with elderly acute cerebral infarction were categorized into simplex acute cerebral infarction group(SACI group,n=75),complicated systemic inflammatory response syndrome group(SIRS group,n=45),and a group of multiple organ dysfunction syndrome caused by complicated SIRS(MODS group,n=29).Forty healthy persons with matched age and sex were set as the control group.The serum CRP was determined by latex agglutination turbidmetric method and compared among the groups.Results The incidence of SIRS was 37.5%(n=45);29 patients had complication of MODS and the rate was 24.2%;and 64.4% of the patients with SIRS had complication of MODS.The positive rate of CRP and the level of CRP were significantly different among the four groups(P0.01;MODS group SIRS group SACI group control group),and the difference was significant between each group(P0.05).Conclusion Acute cerebral infarction in elderly patients are often accompanied with SIRS or MODS.Serum CRP level can be a useful indicator for the complicated SIRS or MODS,and thus provides useful information for the the clinical diagnosis and evaluation of cerebral infarction.