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2003•Xinjiang Yike Daxue xuebaoRequires access

A study on association of insertion/deletion polymorphism of the angiotensin coverting enzyme gene with essential hypertension in Xinjiang

Zhang Yuan

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Abstract

Objective: To asses whether the insertion/deletion(I/D) polymorphism of angiotensin coverting enzyme (ACE) gene was associated with essential hypertension in xinjiang. Methods: I/D polymorphism of ACE was determined by polymerase chain reaction (PCR) in 72 normal controls, 78 patients with essential hypertension. Results: The frequencies of DD gene type (0.30) and deletion allele (0.53) among essential hypertension were significantly higher than those (0.14) among control subjects (0.375). Conclusion: The results indicate that a deletion polymorphism of ACE gene probably may be the risk factor in essential hypertension in xinjiang.

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What this paper is about

Objective: To asses whether the insertion/deletion(I/D) polymorphism of angiotensin coverting enzyme (ACE) gene was associated with essential hypertension in xinjiang. Methods: I/D polymorphism of ACE was determined by polymerase chain reaction (PCR) in 72 normal controls, 78 patients with essential hypertension. Results: The frequencies of DD gene type (0.30) and deletion allele (0.53) among essential hypertension were significantly higher than those (0.14) among control subjects (0.375). Conclusion: The results indicate that a deletion polymorphism of ACE gene probably may be the risk factor in essential hypertension in xinjiang.

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Available abstract

Objective: To asses whether the insertion/deletion(I/D) polymorphism of angiotensin coverting enzyme (ACE) gene was associated with essential hypertension in xinjiang. Methods: I/D polymorphism of ACE was determined by polymerase chain reaction (PCR) in 72 normal controls, 78 patients with essential hypertension. Results: The frequencies of DD gene type (0.30) and deletion allele (0.53) among essential hypertension were significantly higher than those (0.14) among control subjects (0.375). Conclusion: The results indicate that a deletion polymorphism of ACE gene probably may be the risk factor in essential hypertension in xinjiang.

Key concepts: Essential hypertension, Allele, Gene, Polymerase chain reaction, Angiotensin-converting enzyme, Polymorphism (computer science), Genetics, Genotype

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