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Research Progress of Sex Determining Gene in Mammalian Animals

Di Liu

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Abstract

Mammalian sexual development is characterized by three distinct, sequential events: the establishment of sex chromosomal at fertilization (XY,XX) ; gonadal development and differentiation (testis or ovary) , and finally, the acquisition of the proper sexual phenotype (male or female) . It' s found that testis determining factor (TDF) is sex determining region on Y chromosome (SRY), and some sex determining genes are identified involved in sex determination or sex reversal, such as SOX9, DAX1, SF1, WT1, GATA - 4 and so on. The research progress and future perspectives of sex determining gene in mammalian animals were reviewed.

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What this paper is about

Mammalian sexual development is characterized by three distinct, sequential events: the establishment of sex chromosomal at fertilization (XY,XX) ; gonadal development and differentiation (testis or ovary) , and finally, the acquisition of the proper sexual phenotype (male or female) . It' s found that testis determining factor (TDF) is sex determining region on Y chromosome (SRY), and some sex determining genes are identified involved in sex determination or sex reversal, such as SOX9, DAX1, SF1, WT1, GATA - 4 and so on. The research progress and future perspectives of sex determining gene in mammalian animals were reviewed.

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Available abstract

Mammalian sexual development is characterized by three distinct, sequential events: the establishment of sex chromosomal at fertilization (XY,XX) ; gonadal development and differentiation (testis or ovary) , and finally, the acquisition of the proper sexual phenotype (male or female) . It' s found that testis determining factor (TDF) is sex determining region on Y chromosome (SRY), and some sex determining genes are identified involved in sex determination or sex reversal, such as SOX9, DAX1, SF1, WT1, GATA - 4 and so on. The research progress and future perspectives of sex determining gene in mammalian animals were reviewed.

Key concepts: Testis determining factor, SOX9, Biology, Sex reversal, Sexual differentiation, Y chromosome, Disorders of sex development, Gene

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