2009•Unpublished venueRequires access
The Influence of Wuchong Powder on Expression of Nephrin mRNA And VEGF mRNA on C-BSA-induced Nephrotic Rats' Podocyte
Guo Wei
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Abstract
Objective:To observe the the influence of Wuchong powder on expression of Nephrin mRNA and vascular endothelial growth factor(VEGF) mRNA on C-BSA-induced nephrotic rats'glomeruluses.Methods:To established the rat models with nephritis induced by C-BSA,SD rats were randomly divided into the high-dosage of Wuchong powder group(TCM1),low-dosage of Wuchong powder group(TCM2),tripterygium group(GTW),model group,blank group.Each group had 7 rats.Toobserve daily urine protein dose,Serum albumin,cholesterol,expression of Nephrin mRNA and VEGF mRNA of glomerulus podocyte.Results:Wuchong powder could markedly reduce the level of urinary protein compared with model group(P0.01),increases the expression of Nephrin mRNA and Serum albumin,decrease the expression of VEGF mRNA and cholesterol.Conclusions:Wuchong powder had marked treatment on C-BSA-induced nephrotic rats',increases the Serum albumin,improve cholesterol,recover the expression and distribution of podocyte's associated protein,reverse the podocytepathy.