2009•Unpublished venueRequires access
The Influence of Qilou Particle on Expression of Nephrin mRNA on Adriamycin(ADR)-induced Nephrotic Rats' Podocyte
Ying Li
Open publisher page 1 citations
Abstract
Objective:To observe the influence of Qilou particle on expression of Nephrin mRNA on adriamycin(ADR)-induced nephrotic rats' glomeruluses podocyte.Methods:To established the rat models with nephritis induced by ADR,SD rats were randomly divided into the high-dosage of Qilou particle group(TCM1),low-dosage of Qilou particle group(TCM2),tripterygium group(GTW),model group,blank group.Each group had 7 rats.The medication was started 6 days after modeling by tail vein injection.All the rats were killed 30 days after modeling.To observe daily urine protein dose,liver function,renal function,expression of Nephrin mRNA of glomeruluses podocyte.Results:Qilou particle could markedly reduce the level of urinary protein compared with model group(P0.01),have no damage to the liver(P0.05),increase the expression of Nephrin mRNA.Conclusions:Qilou particle had marked treatment on rat model of podocyte iujury to reduce proteinuria,improve rat renal function and foot process fusion,recover the expression and distribution of podocyte's associated protein,reverse the podocytepathy.