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2003•Tianjin Yike Daxue xuebaoRequires access

Genetic polymorphism of the TH01、TPOX in han population in Tianjin

Jing Lian-ping

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Abstract

Objective: To understand the distribution of genes and genotypes of TH01 ?TPOX loci in Han population in Tianjin.Methods:EDTA-blood specimens were collected from the unrelated individuals. The DNA samples were extracted with TKM method and were amplified by PCR technique. Polyacrylamide gel electrophoresis followed by silver staining were used to analyze the polymorphism of TH01 TPOX loci.Results:5 alleles and 14 genotypes of TH01, 5 alleles and 14 genotypes of TPOX were observed. The genotype distributions in two loci were in accordance with Hardy-Weinberg equilibrium.The heterozygosities observed (H)were 0.658 5?0.628 1 for TH01 and TPOX respectively.The discriminating powers(DP) were 0.817 4?0.813 7. Conclusion: The results demonstrated that TH01 and TPOX locus is highly polymorphic and can be used inforensic identification and genetic research of population as well.

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Objective: To understand the distribution of genes and genotypes of TH01 ?TPOX loci in Han population in Tianjin.Methods:EDTA-blood specimens were collected from the unrelated individuals. The DNA samples were extracted with TKM method and were amplified by PCR technique. Polyacrylamide gel electrophoresis followed by silver staining were used to analyze the polymorphism of TH01 TPOX loci.Results:5 alleles and 14 genotypes of TH01, 5 alleles and 14 genotypes of TPOX were observed. The genotype distributions in two loci were in accordance with Hardy-Weinberg equilibrium.The heterozygosities observed (H)were 0.658 5?0.628 1 for TH01 and TPOX respectively.The discriminating powers(DP) were 0.817 4?0.813 7. Conclusion: The results demonstrated that TH01 and TPOX locus is highly polymorphic and can be used inforensic identification and genetic research of population as well.

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Available abstract

Objective: To understand the distribution of genes and genotypes of TH01 ?TPOX loci in Han population in Tianjin.Methods:EDTA-blood specimens were collected from the unrelated individuals. The DNA samples were extracted with TKM method and were amplified by PCR technique. Polyacrylamide gel electrophoresis followed by silver staining were used to analyze the polymorphism of TH01 TPOX loci.Results:5 alleles and 14 genotypes of TH01, 5 alleles and 14 genotypes of TPOX were observed. The genotype distributions in two loci were in accordance with Hardy-Weinberg equilibrium.The heterozygosities observed (H)were 0.658 5?0.628 1 for TH01 and TPOX respectively.The discriminating powers(DP) were 0.817 4?0.813 7. Conclusion: The results demonstrated that TH01 and TPOX locus is highly polymorphic and can be used inforensic identification and genetic research of population as well.

Key concepts: Genotype, Locus (genetics), Allele, Genetics, Biology, Population, Genotype frequency, Allele frequency

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