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2008•Chinese Journal of Birth Health & HeredityRequires access

A study of genetic polymorphism of the STR locus TH01 and TPOX in Han population in Wenzhou

Hongqin Zhang

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Abstract

Objective:To study genetic polymorphism of TH01 and TPOX in Han population in Wenzhou. Methods: DNA was extracted with chelex-100 method from EDTA-blood samples of 197 unrelated individuals in Wenzhou and amplified with PCR technique. The PCR products were analyzed by PAG vertical electrophoresis and silver-stain. Results: 6 alleles and 16 genotypes of TH01,5 alleles and 12 genotypes of TPOXwas observed. The heterozygosities of TH01 and TPOX are 0.659 and 0.619; The power of exclusion are 0.367 and 0.315;The power of discriminating are 0.839 and 0.766 .Conclusion: The heterozygosities of TH01 and TPOX are high and the frequencies was in accordance with Hardy-Weinberg equilibrium (P0.05),so the three loci can be used in forensic medicine and in other genetic researches.

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What this paper is about

Objective:To study genetic polymorphism of TH01 and TPOX in Han population in Wenzhou. Methods: DNA was extracted with chelex-100 method from EDTA-blood samples of 197 unrelated individuals in Wenzhou and amplified with PCR technique. The PCR products were analyzed by PAG vertical electrophoresis and silver-stain. Results: 6 alleles and 16 genotypes of TH01,5 alleles and 12 genotypes of TPOXwas observed. The heterozygosities of TH01 and TPOX are 0.659 and 0.619; The power of exclusion are 0.367 and 0.315;The power of discriminating are 0.839 and 0.766 .Conclusion: The heterozygosities of TH01 and TPOX are high and the frequencies was in accordance with Hardy-Weinberg equilibrium (P0.05),so the three loci can be used in forensic medicine and in other genetic researches.

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Available abstract

Objective:To study genetic polymorphism of TH01 and TPOX in Han population in Wenzhou. Methods: DNA was extracted with chelex-100 method from EDTA-blood samples of 197 unrelated individuals in Wenzhou and amplified with PCR technique. The PCR products were analyzed by PAG vertical electrophoresis and silver-stain. Results: 6 alleles and 16 genotypes of TH01,5 alleles and 12 genotypes of TPOXwas observed. The heterozygosities of TH01 and TPOX are 0.659 and 0.619; The power of exclusion are 0.367 and 0.315;The power of discriminating are 0.839 and 0.766 .Conclusion: The heterozygosities of TH01 and TPOX are high and the frequencies was in accordance with Hardy-Weinberg equilibrium (P0.05),so the three loci can be used in forensic medicine and in other genetic researches.

Key concepts: Genotype, Allele, Biology, Genetics, Locus (genetics), Genotype frequency, Population, Allele frequency

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