Study on the Long-term Effect of α-1b Interferon in Treatment of Chronic Hepatitis B

OBJECTIVE:To study the long-term therapetuic effect of domestic recombination α-1b interferon on chronic hepatitis B.METHODS:In a prospective study,taking chronic hepatitis B patients without receiving interferon as control,we observed the long-term efficacy of α-1b interferon in treatment of 33 cases of chronic hepatitis B with an average follow-up period of 5.2 years.RESULTS:(1)In interferon group,the total effective rate and serum HBeAg,HBV-DNA negative-turn rates were 75.7%?84.8% and 84.4%;in control group,the serum HBeAg,HBV-DNA negative-turn rates were 63.3% and 54.2%,respectively.There were significant differences between two groups(P0.05).(2)After 1?2?5?8 and 10 years treatment,the corresponding negative-turn rates of HBeAg were 51.5%?48.5%?69.6%?84.8% and 87% and the negative-turn rates of HBV-DNA were 52.5%?48.5%?84.4%?86.6% and 86.6% respectively.The results indicated that in follow-up period,the negative-turn rates of HBV markers increased with time because of the long-term sustained action of α-1b interferon.(3)The incidence of liver fibrosis was lower in interferon group than that in control group.CONCLUSION:Domestic α-1b interferon has long-term sustained anti-HBV effect on chronic hepatitis B and can improve the prognosis and potentially prevent liver fibrosis in hepatitis patients.