ScholarLens Back to search
2001•Chinese Heart JournalRequires access

Relationship between Type C natriuretic peptide and hypertension and left ventricle hypertrophy

Hai Wang

Open publisher page 0 citations

Abstract

AIM:To investigate the correlations between plasma Type C natriuretic peptide(CNP) levels and the degree of hypertension and left ventricle hypertrophy in stroke-prone spontaneously hypertensive rats (SHR_ SP ). METHODS:The plasma concentrations of CNP were measured by means of radioimmunoassay in SHR_ SP and compared with those of normotensive rats (Wistar-Kyoto rat,WKY). RESUTLS:Systolic blood pressure (SBP) and left ventricle puls septum (LV+S) weight and (LV+S)/body weight (BW) ratio were markedly higher in SHR_ SP than in WKY (P0.01). Plasma CNP levels were 145±42 ng/L and 72±11 ng/L in SHR_ SP and in WKY respectively,and the difference were significant (P0.01). There were positive correlations between CNP and SBP as well as CNP and (LV+S)/BW (P0.05),while CNP had no significant correlations with heart rate (HR),right ventricle (RV) weight and BW(P0.05). CONCLUSION:CNP may reflex the degree of hypertension and left ventricle hypertrophy.

About this research paper

What this paper is about

AIM:To investigate the correlations between plasma Type C natriuretic peptide(CNP) levels and the degree of hypertension and left ventricle hypertrophy in stroke-prone spontaneously hypertensive rats (SHR_ SP ). METHODS:The plasma concentrations of CNP were measured by means of radioimmunoassay in SHR_ SP and compared with those of normotensive rats (Wistar-Kyoto rat,WKY). RESUTLS:Systolic blood pressure (SBP) and left ventricle puls septum (LV+S) weight and (LV+S)/body weight (BW) ratio were markedly higher in SHR_ SP than in WKY (P0.01). Plasma CNP levels were 145±42 ng/L and 72±11 ng/L in SHR_ SP and in WKY respectively,and the difference were significant (P0.01). There were positive correlations between CNP and SBP as well as CNP and (LV+S)/BW (P0.05),while CNP had no significant correlations with heart rate (HR),right ventricle (RV) weight and BW(P0.05). CONCLUSION:CNP may reflex the degree of hypertension and left ventricle hypertrophy.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

AIM:To investigate the correlations between plasma Type C natriuretic peptide(CNP) levels and the degree of hypertension and left ventricle hypertrophy in stroke-prone spontaneously hypertensive rats (SHR_ SP ). METHODS:The plasma concentrations of CNP were measured by means of radioimmunoassay in SHR_ SP and compared with those of normotensive rats (Wistar-Kyoto rat,WKY). RESUTLS:Systolic blood pressure (SBP) and left ventricle puls septum (LV+S) weight and (LV+S)/body weight (BW) ratio were markedly higher in SHR_ SP than in WKY (P0.01). Plasma CNP levels were 145±42 ng/L and 72±11 ng/L in SHR_ SP and in WKY respectively,and the difference were significant (P0.01). There were positive correlations between CNP and SBP as well as CNP and (LV+S)/BW (P0.05),while CNP had no significant correlations with heart rate (HR),right ventricle (RV) weight and BW(P0.05). CONCLUSION:CNP may reflex the degree of hypertension and left ventricle hypertrophy.

Key concepts: Internal medicine, Ventricle, Endocrinology, Blood pressure, Muscle hypertrophy, Natriuretic peptide, Left ventricular hypertrophy, Medicine

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Relationship between Type C natriuretic peptide and hypertension and left ventricle hypertrophy — Research Paper | ScholarLens