Relationship between plasma BNP levels and major adverse cardiovascular events in ACS patients

Objective To investigate the relationship between brain natriuretic peptide(BNP)and major adverse cardiovascular events(MACE)in acute coronary syndrome(ACS)patients.Methods Two hundred and ten ACS patients,treated in this hospital,were enrolled.Plasma BNP was detected,and MACE during hospitalization and within 30days after discharging were collected.According to plasma BNP level,all patients were divided into group A,with BNP100pg/mL,and group B,with BNP≥100pg/mL.MACE were compared between the two groups.Results The mean age of group B was(65.9±11.4)years,which was significantly higher than the(62.6±10.3)years of group A(P=0.03).The proportion of patients with ST segment elevation myocardial infarction(STEMI)in group B was 53.7%,which was significantly higher than the 34.3%in group A(P=0.005).However,the differences of sex,diabetes,hypertension,dyslipidemia and smoking were not statistically significant(P0.05).During hospitalization,incidence rate of MACE in group B was 17.6%,which was higher than the 4.9% of group A(P=0.004),and cardiac mortality and recurrence of myocardial infarction in group B were also higher than group A(P0.05).Onemonth after discharging,incidence rate of MACE in group B was 33.3%,which was higher than the 9.8%in group A(P0.01),and cardiac mortality,recurrence of myocardial infarction and re-revascularization of group B were also higher than group A(P0.05).Conclusion Incidence rate of short-term MACE might be increased in ACS patients with the increasing of plasma BNP levels.To ACS patients with BNP≥100pg/mL,more attention should be paid in clinical works.