Relationship between Serum Brain Natriuretic Peptide and Major Adverse Cardiac Events in Patients with Acute Coronary Syndrome

Objective To explore the correlation of serum brain natriuretic peptide(BNP) and the major adverse cardiac events(MACEs) in the patients with acute coronary syndrome(ACS) . Methods Ninty-eight patients whose data were available were enrolled in this study,serum BNP level was measured in the patients with ACS during 24 hours after admission,and the patients were divided into 3 groups based on the BNP level,Group A:BNP level≤100ng/mL;Group B:100ng/ml BNP level 400ng/mL;Group C:BNP level≥400ng/mL. And the total mortality and MACEs including death,recurrent angina,heart failure and re-admission for any reason in hospitalization,were analyzed at 1 month and 3 months after hospital discharge. Results A three-month follow-up showed that no cardiac death and re-myocardial infarction happened in Group A,there were two cases of cardiac death and 2 cases of re-myocardial infarction in Group B,and two cases of cardiac death and 2 cases of re-myocardial infarction in Group C. There was a significant difference in the occurrence of MACEs between the three groups,with a higher MACE occurrence of Group C than that of Group B and in turn,than that of Group A(P0.01) . Conclusion The higher the BNP level in the patients with ACS is on admission,the higher the MACE occurrence may be. The determination of serum BNP level may predict the MACE occurrence rate in the patients with ACS.