The efficacy and safety of solifenacin vesicare therapy in patients with overactive bladder

Objective To observe and evaluate the efficacy and safety of solifenacin vesicare therapy in patients with overactive bladder.Methods 60 patients with overactive bladder were enrolled in the trial and assigned to treatment group and control group(n=30 each).Solifenacin vesicare was taken(5mg qd after breakfast for 4 weeks)in treatment group,and tolterodine was taken(2mg bid for 4 weeks)in control group.The efficacy of solifenacin vesicare and tolterodine was assessed by OABSS and IPSS at 0-week,2nd-week,4th-week.Results After treatment,two groups of patients with urinary urgency,urinary frequency,nocturia increased,urinary incontinence symptoms were improved apparently,the difference was not statistically significant(P0.05).Adverse reactions of drug in treatment group including xerostoma,visual field obscure,palpitations,rash and constipation were all lower than those in control group(P0.05).Conclusion The rociverine therapy for patients with bladder spasm after transurethral resection of prostate is effective and safe.