Effect of terbutaline on alveolar liquid clearance in rats after smoke inhalation injury

AIM To explore the effect of terbutaline on alveolar epithelial liquid clearance after smoke inhalation injury METHODS Rats inhalation injury model was carried out by exposed in wood smoke Terbutaline solution(10 -4 mol·L -1 , 5 ml·kg -1 )was instilled into trachea at 24 h after smoke inhalation One hour later, the alveolar liquid clearance rate(ALC), total lung water content(TWL), extravascular lung water content(EVLW) and arterial blood gases were examinedRESULTS The ALC was reduced by 458%, TWL and EVLW were markedly rose, and with severe hypoxemia Compared with injury rats, terbutaline increased ALC by approximately 60%, decreased TWL and EVLW, and improved hypoxemia The terbutaline effect was partly blocked by amiloride and ouabain, the inhibitors of sodium transportCONCLUSION Terbutaline can stimulate alveolar liquid clearance by increasing sodium transport