Inhibitory effect of terbutaline on pulmonary edema in rats after acute lung injury induced by oleic acid

Objective To explore the inhibitory effect of terbutaline on pulmonary edema in rats after acute lung injury induced by oleic acid.Methods Rats were intravenously infused with oleic acid(0.25 ml/kg) to establish pulmonary edema models and then were randomly divided into Control, Injured and Terbutaline groups.One hour later,terbutaline solution(10-4M,5ml/kg)was instilled into trachea in terbutaline group.The pulmonary microvascular permeability(PMVP),total lung water content(TLW),extravascular lung water content(EVLW) and arterial blood gases were examined at 6,12 and 24 hours respectively after infusion.Results The PMVP,TLW and EVLW were markedly increased,with ensuing severe hypoxemia.Compared with injured rats,terbutaline significantly decreased PMVP,TWL and EVLW,and improved hypoxemia.Conclusion Terbutaline can reduce edema accumulation and improve hypoxia in acute lung injury,and may have therapeutical effect on pulmonary edema after acute lung injury.