The Pharmacokinetic Comparison between Thiamphenicol and HP-β-CD Thiamphenicol in Rabbit

The pharmacokinetic regulations of thiamphenicol and HP-β-CD thiamphenicol were investigated by taken oral administration at a dosage of 30 mg/kg to healthy rabbits. The concentration of thiamphenicol in plasma was determined by RP-HPLC, and the data of concentration-time were analyzed by pharmacokinetic-compartment analysis soft(3P97). The data of concentration-time after oral administration of thiamphenicol and HP-β-CD thiamphenicol were all fitted to a one -compartment open model with first -order absorption. The main pharmacokinetic parameters of thiamphenicol were as follows: Lagtime(0. 05 ±0. 02)h, t1/ 2ka(0. 83 ±0. 02)h, t1/ 2ke(2.27 ±0. 31)h, T(peak) (1. 84 ±0. 12)h, C(max)(6. 98 ±0. 95)mg/ L, AUC(34. 98 ±0. 68)mg/(L·h)and F(110. 74 ±0. 02)%. The main pharmacokinetic parameters of HP-β-CD thiamphenicol were as follows: Lagtime (0. 02 ±0. 01) h, t1/2ka (0. 91 ± 0. 16) h, t1/2ke (0.86 ±0. 15) h, T(peak) (0.96 ±0. 07) h, C (max) (8.59 ±0. 55) mg/ L, AUC (43. 02 ±0. 87) mg/ (L·h), F (142.07 ±0. 02) %. The pharmacokinetic characteristics of HP-β-CD thiamphenicol in healthy rabbits manifested the rapid and complete absorption, wide distribution, rapid elimination and the high bioavailability by the oral routes.