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Effect of valproic acid on the expression of VEGF and bFGF in Kasumi-1 cell

Hao Changlai

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Abstract

Objective To investigate the mechanism of action of valproic acid(VPA) on the proliferation and inhibition of angiogenesis of Kasumi-1 cell.MethodsKasumi-1 cell was treated with VPA in different concentrations for different time.The mRNA and protein expression of VEGF and bFGF were detected by RT-PCR and Western Blot assays.ResultsAfter treated by the VPA,the mRNA and protein expression of VEGF decreased,the expression of bFGF mRNA increased,both in dose-dependent manner.ConclusionVPA can inhibit the angiogenesis and proliferation of Kasumi-1 cell,by regulating the expression of VEGF and bFGF.

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What this paper is about

Objective To investigate the mechanism of action of valproic acid(VPA) on the proliferation and inhibition of angiogenesis of Kasumi-1 cell.MethodsKasumi-1 cell was treated with VPA in different concentrations for different time.The mRNA and protein expression of VEGF and bFGF were detected by RT-PCR and Western Blot assays.ResultsAfter treated by the VPA,the mRNA and protein expression of VEGF decreased,the expression of bFGF mRNA increased,both in dose-dependent manner.ConclusionVPA can inhibit the angiogenesis and proliferation of Kasumi-1 cell,by regulating the expression of VEGF and bFGF.

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Available abstract

Objective To investigate the mechanism of action of valproic acid(VPA) on the proliferation and inhibition of angiogenesis of Kasumi-1 cell.MethodsKasumi-1 cell was treated with VPA in different concentrations for different time.The mRNA and protein expression of VEGF and bFGF were detected by RT-PCR and Western Blot assays.ResultsAfter treated by the VPA,the mRNA and protein expression of VEGF decreased,the expression of bFGF mRNA increased,both in dose-dependent manner.ConclusionVPA can inhibit the angiogenesis and proliferation of Kasumi-1 cell,by regulating the expression of VEGF and bFGF.

Key concepts: Valproic Acid, Angiogenesis, Cell growth, Messenger RNA, Western blot, Chemistry, Cell, Protein expression

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