C-myc and PCNA expression in lung cancer and its significance

Objective:To investigate the expression of C-myc and PCNA(proliferating cell nuclear antigen) in lung cancer and normal lung tissue or lung tissue of bullae and the relationship to the development of lung cancer.Methods: Immunohistochemical staining was used to measure expression of C-myc and PCNA in 50 patients with primary lung cancer(squamous cell carcinoma in 24 cases,19 cases of adenocarcinoma,adenosquamous carcinoma in 4 cases,3 cases of small cell lung cancer) and 16 normal lung tissues or lung bullae tissue.Results: The expression of C-myc,PCNA positive rates were 66%(33/50),74%(37/50) in total of 50 cases of primary lung cancer,no expression of two antibodies observed in normal tissue.The expression of C-myc and PCNA positive rate was significantly higher in lung cancer than lung tissue,and there was no expression of C-myc in 3 cases of small cell lung cancer.Conclusion: C-myc expression in lung cancer was no correlation to PCNA;increased expression of C-myc and PCNA which was developed in the early stage in lung cancer had no association with the staging of lung cancer;they may be related to the development of lung cancer and are helpful to the early diagnosis and molecular targeting therapy.