Comparison of Zhibitai and Simvastatin in hypolipemic effect and atheromatous plaque resolution of carotid artery in patients with hyperlipemia

【Objective】 To compare the effects of Zhibitai versus Simvastatin on lipid-lowering and atheromatous plaque resolution of carotid artery in patients with hyperlipemia.【Methods】 A total of 139 patients with hyperlipemia were randomly divided into Zhibitai group(n =69) and Simvastatin group(n =70),and both groups received Zhibitai(480 mg/d) and Simvastatin(20 mg/d) for 12 months,respectively.The blood lipid,creatine kinase,liver and renal function,and the carotid plaques before and after the treatment were determined by biochemical analyzer and Doppler ultrasonography,respectively.【Results】 TC,TG and LDL-C levels decreased(P 0.05),and HDL-C contents increased significantly(P 0.05) after Zhibitai or Simvastatin treatment.The atheromatous plaques of carotidartery in both groups showed obvious resolution,the difference between two groups was not statistically significant(P 0.05).【Conclusion】 The lipid-lowering efficacy and carotid plaque resolution of Zhibitai are similar to those of simvastain in patients with hyperlipemia.