Clinical Study of Insulin Combined with Metformin in the Treatment of Type 2 Diabetes Mellitus

Objective To discuss the clinical value of insulin combined with metformin in the treatment of type 2 diabetes mellitus. Methods One hundred and twenty patients with type 2 diabetes mellitus in our hospital were randomly divided into two groups, with 60 cases in each group. Patients in the control group were treated with insulin, while patients in the observation group were treated with insulin combined with metformin. The fasting glucose, two-hour postprandial blood glucose, glycosylated hemoglobin, body weight, daily insulin usage and the time to standard blood glucose before and after treatment were recorded to evaluate the clinical effect. Results After treatment, the fasting glucose, two-hour postprandial blood glucose, glycosylated hemoglobin of both groups improved compared with those before treatment(P 0.05). The increase body weight was(1.9 ± 0.4) kg in the observation group, significantly lower than(4.5 ± 1.2) kg of control group. The daily insulin usage was(42 ± 8) U of observation group, significantly lower than(57 ± 11) U of control group(P 0.05). The time to standard blood glucose was(8.5 ± 0.3) d in the observation group, significantly lower than(12.4 ± 0.4) d of control group(P 0.05). Conclusions The use of insulin combined with metformin in the treatment of type 2 diabetes mellitus can effectively improve patient's two-hour postprandial blood glucose, reduce the daily insulin usage, shorten the time to standard blood glucose and avoid excessive growth of body weight, which is worthy of clinical application.