The protective effect of sevoflurane postconditioning on focal cerebral ischemia reperfusioon injury

Objective To investigate the protective effect of sevoflurane postconditioning with different concentrations given at the onset of reperfusion on focal cerebral ischemic-reperfusion injury.Methods Fifty male SD rats were randomly assigned to five groups(with 10 rats each):control group,oxygen inhalation group and 0.5MAC,1.0MAC,1.5MAC sevoflurane postconditioning group.All animals were subjected to the right middle cerebral artery occlusion(MCAO) for 120min, followed by reperfusion for 72h.The animals in 0.5,1.0 and 1.5MAC group were given 0.5,1.0 and 1.5MAC sevoflurane inhalation from 20min before to 10min after reperfusion.The neurological deficit scores (NDS) were recorded at 24,48,and 72h after reperfusion.Infarct volume percentage was determined after the last NDS assessment.Results The infarct volume percentage ratio of 0.5,1.0 and 1.5MAC group were 0.39±0.03,0.31±0.03 and 0.24±0.03,respectively (P0.05, among the groups),which were significantly smaller than 0.53±0.05 in control group (P0.05).The infarct volume percentage of O2 group was 0.51±0.05,which was not significantly different with that of control group. NDS of 24,48h and 72h after reperfusion in all sevoflurane groups was significantly higher than that in control and oxygen groups.Conclusion 0.5,1.0 and 1.5MAC sevoflurane postconditioning has a significant neuroprotective effect in a dose-dependent manner.