Dose-dependent effects of folic acid and folic acid on the plasma homocysteine level in the patients with coronary heart disease

Objective To investigate the effects of different dose of folic acid and vitamin B on the plasma homocysteine level in the patients with coronary heart disease. Methods 90 patients with the plasma homocysteine level increased were divided randomly into 3 groups: A, B and C group, there were 30 patients in each group. A and B group were treated with different doses of folic acid and vitamin B, C group were not treated. Both the homocysteine level were measured before and after four weeks' treatment. Results The homocysteine level in the patients with coronary heart disease was significantly decreased after four weeks' treatment in treapy groups. The difference of the treapy groups and C group was significant (P0.001). Compared with the homocysteine level before and after the treatment of A and B group was significant (P0.001). But there was no difference between A and B groups after the treatment(P0.05). Conclusion The homocysteine level in the patients with coronary heart disease was decreased after the treatment of folic acid and vitamin B. The degree of the homocysteine decreased had no relationship with the doses of the medicine. Low-dose medcine could achieved the protective effect and might be selected as the protective medcine of the early-term patients with coronary heart disease.