Correlation on the P~(53) protein expression between the primary carcinoma and metastatic carcinoma in human breast

Objective To study the relationship between the different expression of P 53 protein in primary and metastatic human breast carcinoma and its invasiveness. Methods Forty-two paraffine embedded tissue sections were studied with immunohisto-chemical ABC staining to observe P 53 protein expression in original and metastic tumor.Results The abnormal rate of P 53 protein expression was 59.52%(25/42).The original group was 45.45%(10/22), and that of metastatic group was 75.00%(15/20). The positive rate of the patients who are above 45 years old was 80.00%(16/20), while the younger group was 40.91%(9/22).The difference of the rate was significantly in original tumor,metastatic tumor and age. Conclusion The heterogencity lie between the primary breast carcinoma and the metastatic breast carcinoma.