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2008•Journal of psychiatryRequires access

Acarbose in the treatment of schizophrenia with impaired glucose tolerance:a random-control study

Ju-ying Ji

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Abstract

Objective To investigate the efficacy and side effects of acarbose in the treatment of schizophrenia with impaired glucose tolerance.Methods Sixty schizophrenia were randomly divided into two groups treated with acarbose or metformin respectively for treatment of 4 weeks.The fasting plasma glucose(FPG),2-hour plasma glucose tolerance test(2HPG) and glycated hemoglobin AIC(HbA1c) were measured before and after treatment.Results FPG,2HPG and HbA1c had significantly reduced in two groups after 4-week treatment(P0.05).After treatment,2HPG had significantly more reduced in acarbose group than metformin group(P0.05),and no significant differences were found in the FPG and HbA1c between two groups(P0.05).The prevalence of side effects were similar in two groups.Conclusion Acarbose is an effective drug in the treatment of impaired glucose tolerance in schizophrenia.

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What this paper is about

Objective To investigate the efficacy and side effects of acarbose in the treatment of schizophrenia with impaired glucose tolerance.Methods Sixty schizophrenia were randomly divided into two groups treated with acarbose or metformin respectively for treatment of 4 weeks.The fasting plasma glucose(FPG),2-hour plasma glucose tolerance test(2HPG) and glycated hemoglobin AIC(HbA1c) were measured before and after treatment.Results FPG,2HPG and HbA1c had significantly reduced in two groups after 4-week treatment(P0.05).After treatment,2HPG had significantly more reduced in acarbose group than metformin group(P0.05),and no significant differences were found in the FPG and HbA1c between two groups(P0.05).The prevalence of side effects were similar in two groups.Conclusion Acarbose is an effective drug in the treatment of impaired glucose tolerance in schizophrenia.

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Available abstract

Objective To investigate the efficacy and side effects of acarbose in the treatment of schizophrenia with impaired glucose tolerance.Methods Sixty schizophrenia were randomly divided into two groups treated with acarbose or metformin respectively for treatment of 4 weeks.The fasting plasma glucose(FPG),2-hour plasma glucose tolerance test(2HPG) and glycated hemoglobin AIC(HbA1c) were measured before and after treatment.Results FPG,2HPG and HbA1c had significantly reduced in two groups after 4-week treatment(P0.05).After treatment,2HPG had significantly more reduced in acarbose group than metformin group(P0.05),and no significant differences were found in the FPG and HbA1c between two groups(P0.05).The prevalence of side effects were similar in two groups.Conclusion Acarbose is an effective drug in the treatment of impaired glucose tolerance in schizophrenia.

Key concepts: Acarbose, Impaired glucose tolerance, Metformin, Glycated hemoglobin, Plasma glucose, Internal medicine, Schizophrenia (object-oriented programming), Medicine

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