The effect of combined active immunotherapy on the patients with unexplained habitual abortion

Objective: To investigate the effect of active immunotherapy combined with human chorionic gonadotropin (hCG) or progesterone on the patients with unexplained habitual abortion (UHA). Method: Fifty patients with UHA were treated by active immunotherapy using lymphocytes, combined with hCG or progesterone. Results: Among 29 pregnant women, there were 21 live births, 2 at second trimester, 2 at third trimester, and 4 miscarriages, which calculated a total successful pregnancy rate of 86%. There was no significant difference in the successful pregnancy rate of the patients either combined with hCG (88%) or progesterone (85%). After active immunotherapy, three of 29 pregnant patients had positive blocking- antibody, and two of them obtained successful pregnancy. The successful pregnant rate of the negative patients was 89% (23/26). There was no significant difference in two groups. Conclusions: It is an effective method of active immunotherapy, combined with hCG or progesterone, for the patients of unexplained habitual abortion. There is no significant difference of successful pregnancy in the patients whether combined with hCG or progesterone. The blocking-antibody is not a predictor for successful pregnancy.