The clinical research of treatment of unexplained recurrent spontaneous abortion by immunotherapy combined with HCG and Progesterone

Objective:To compare the clinical effect of treatment the patients with unexplained recurrent spontaneous abortion(URSA) by immunotherapy only and immunotherapy combined with human chorionic gonadotropin(HCG),Progesterone.To evaluate the proper therapeutic strategy to treat URSA. Methods:205 cases with primary or secondary URSA were randomly divided into two groups: 105 cases(group A) were treated with immunotherapy combined with human chorionic gonadotropin(HCG)and Progesterone,100 cases(group B) simply with immunotherapy. Results:The rate of successful pregnancy of group A,B were 90.48%,83% respectively.There were no significant differences between group A and B(P0.05).After active immunotherapy,133 cases had positive blocking-antibody,and 113 cases obtained successful pregnancy.The successful pregnant rate of the positive blocking-antibody patients was 84.96%(113/ 133);The successful pregnant rate of the negative blocking-antibody patients was 80.56%(58/ 72).There was no significant difference in two groups(P0.05). Conclusion:It is unnecessary to treat the whole URSA by immunotherapy combined with HCG and Progesterone,but it is useful when individual need.The blocking-antibody is not a predictor for successful pregnancy.