Analysis efficacy of levofloxacin combined with bifid triple viable capsule in patients with diarrhea predominant irritable bowel syndrome

Objective To evaluate the efficacy of sequential therapy with levofloxacin and bifid triple viable capsule in patients with diarrhea predominant irritable bowel syndrome(IBS-D).Methods 86 patients with IBS-D were divided into three groups randomly.Group A(sequential treatment,29 cases) was given levofloxacin,pinaverium bromide and complex glutamine capsule(GLU) for 1 week,and then took pinaverium bromide,GLU and bifid triple viable capsule(BTVC). Group B(BTVC treatment,29 cases) received pinaverium bromide,GLU and BTVC for 8 weeks.Patients in Group C(routine treatment,28 cases) only took pinaverium bromide and GLU,the period of treatment was 8 weeks.The scores of gastrointestinal symptoms,Bristol score and stool frequency in each group were recorded before and after therapy.Results After treatment,the symptom scores in patients had varying degrees of decline(P 0.01).Compare to group B,the pain frequency, duration of abdominal pain were reduced in Group A(P 0.01).Compare to Group C,the pain frequency,duration of abdominal pain were reduced in Group A(P 0.05).This kind of situation lasted for 4 weeks after stopping medication. After the treatment,the scores of stool frequency(SSF) showed a significant decrease in all three groups(P 0.05).At the end of the 8th week,the SSFs were significantly lower in group A and group B than those in group C(P 0.05),and at the end of the 12th week,SSF remained lower in group A,while not in group B and group C(P 0.05 ).Moreover,the proportion of mucous stool post treatment was lower in group A and group B(P 0.01 ),but not in group C(P 0.05).Conclusion Compare to BTVC treatment and routine treatment,the efficacy of sequential therapy with levofloxacin and bifid triple viable capsule is more effective and durable.It may have more advantages in relieving the symptoms of irritable bowel syndrome.