Preparation of ketoprofen ethosomal gels

Objective To prepare ketoprofen ethosomal gels and study the quality preliminarily.Methods The ketoprofen ethosomes were prepared by injection method.The optimal formulation and preparation were screened by orthogonal experiments.The ethosomal gels were prepared by mixing method.The content of ketoprofen was determined by HPLC and the entrapment efficiency of the ethosomes was measured by dialysis method.Results The shape of the ketoprofen ethosomes was spherical with homogeneous size and the average value of mean particle size was(185.8±58.2)nm.The average encapsulation efficiency was(72.6±3.2)%.The linear range of ketoprofen was 1.5-12.0 μg·mL-1(r=0.999 9).The average recovery of ketoprofen is(99.3±1.5)%.Conclusion The preparation is simple and reasonable with promising repeatability and controllable quality.