Related risk factors of atherosclerosis in elderly high diabetic risk population

Objective To analyse the possible risk factors of atherosclerosis in elderly high diabetic risk population.Methods Elderly individuals who previously had abnormal glycemia but were non-diabetic were recruited.All subjects underwent 75 g oral glucose tolerance test(OGTT) and were divided into normal glucose tolerance(NGT)(n=25),impaired glucose tolerance(IGT)(n=25) and diabetes mellitus(DM)(n=37) groups.Fasting blood samples were taken for examination of lipid profile,adiponectin,MDA,CRP,PAI-1,etc.Carotid arteries were examined by B-ultrasonography.Results In NGT,IGT and DM groups,the numbers of cases with abnormal intima smoothness were 12(48.0%),18(72.0%) and 34(91.1%),and the numbers of subjects having atherosclerosis were 2(8.0%),6(24.0%) and 13(35.1%) respectively,P=0.05.Multivariate logistic regression analysis showed that age,cholesterol,LDL-C,fasting glucose and 2-hour OGTT were independently associated with risk of atherosclerosis.Conclusion Atherosclerosis is serious following the deteriorated glucose metabolism.Age,abnormal blood lipids and high blood glucose are independent risk factors of atherosclerosis.