Abnormal glucose metabolism in subjects with high-risk for diabetes and analysis for its risk factors in Changfeng community,Shanghai

Objective To investigate prevalence of abnormal glucose metabolism in subjects with high-risk for diabetes and its risk factors in Changfeng community of Shanghai.Methods Totally,1197 people aged 40 to 80 years without diabetes history eligible for risk for diabetes from Changfeng community in Shanghai were screened by questionnaire,physical examinations and blood biochemical tests to confirm whether they have risk faetors for diabetes.Oral glucose tolerance test was performed to all the subjects. Results All the subjects could be divided into high-risk group (982) and non-high-risk group (215) according to their results of the tests mentioned above.Prevalence of abnormal glucose metabolism was 47.9% (470/982) in high-risk group,113 with newly diagnosed diabetics [11.5% (113/982)],357 with impaired glucose regulation [36.4% (357/982)],145 with simple impaired fasting glucose (IFG) [14.8% (145/982)],105 with simple impaired glucose intolerance (IGT) [10.7% (105/982)] and 107 with both IFG and IGT [ 10.9% (107/982)],all significantly higher than those in non high-risk group,17.2% (37/215),0.9% (2/215),16.3% (35/215),9.3% (20/215),5.1% (11/215),and 1.9% (4/215),respectively (all P0.05).Logistic regression analysis showed that age,family history of diabetes,body mass index,systolic blood pressure,serum level of triglyceride positively associated with abnormal glucose metabolism and serum level of high-density lipoprotein cholesterol reversely associated with abnormal glucose metabolism.Conclusions Efficiency of such screening for those with abnormal glucose metabolism could be improved when multiphasic screening was applied for the subjects with high-risk for diabetes.Age,family history of diabetes,overweight or obesity,hypertension and dyslipidemia all were main risk factors for abnormal glucose metabolism.