2005•The Journal of Medical Theory and PracticeRequires access

Clinical Significance of Expression of MMP-9 in Human Thyroid Carcinoma

Gelin Liu

Abstract

Objective: To investigate the correlation between the expression of MMP-9 and histological feature,clinical stage, lymph node metastasis in thyroid carcinoma. Methods: The SP immunohistochemical method was employed to determine the expression of MMP-9 in 50 cases of thyroid carcinoma and 20 cases of para-tumorous tissue. Results: The expression of MMP-9 in thyroid carcinoma was remarkablely higher than that in the para-tumorous tissue,the result was uncorrelated with histological feature,but correlated with clinical stage and lymph node metastasis.Conclusions: The expression of MMP-9 is associated with invasion and metastasis of thyroid carcinoma,which may serve as prognosis indexes of thyroid carcinoma.

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Key concepts: Medicine, Thyroid carcinoma, Immunohistochemistry, Stage (stratigraphy), Pathology, Matrix metalloproteinase, Lymph node metastasis, Thyroid