Chromosomal analysis in 235 couples with spontaneous abortions

Objective To evaluate the relationship between karyotype and spontaneous abortions.Methods The peripheral blood in 235 couples with spontaneous abortions were collected. The chromosomal karyotypes of peripheral lymphocytes in 235 couples with spontaneous abortions were analyzed using G-banding after lymphocytes were treated with trypsin.Results There were 37 abnormal karyotypes in 235 couples with spontaneous abortions. The rate of abnormal karyotypes was 7.87%. Abnormal chromosomes were included 1,2,5,7,8,9,12,13,14,15,17,18,20,22 chromosome. These cases included 21 women and 16 men. Among the 37 cases of abnormal karyotypes, 15 cases had balanced translocations, it was 3.19% in all cases(40.54% in abnormal karyotypes); 14 cases had pericentric inversion, it was 2.97% in all cases(37.83% in abnormal karyotypes); 4 cases had chromosome satellite variations, it was 0.85% in all cases(10.81% in abnormal karyotypes); 2 cases had large Y chromosome, it was 0.42% in all cases(5.40% in abnormal karyotypes); 1 case had heter chromatin variations, it was 0.21% in all cases(2.70% in abnormal karyotypes); 1 case had extraordinary small chromosome, it was 0.21% in all cases(2.70% in abnormal karyotypes).Conclusion The spontaneous abortions should be ralated to chromosome abnormalities.