Biological Study of Hemorheology and Erythrocyte Membrane of Model Rats with Stagnation of Phlegm and Blood

Objective: To investigate the changes of biological characteristics of hemorheology and erythrocyte membrane of model rats with stagnation of phlegm and blood. Methods: 40 SD male rats were randomly divided into four groups,with ten in each group. Ten- days group was subdivided into a blank group and a model group; twenty- days group was also subdivided into a blank group and a model group. High fat emulsion was continuously given to model rats intragastrically for 10 days and 20 days respectively,and then determine the hemorheology indexes and activity of erythrocyte membrane. Results: Compared with the blank group,the serous CHO,TG,LDL- C and GLU were increased significantly( P 0. 05),and HDL- C was decreased obviously( P 0. 05); the whole blood viscosity and the plasma viscosity were increased obviously( P 0. 05,P 0. 01); Na+- K+- ATP enzyme and SOD activity were decreased obviously( P 0. 05,P 0. 05),and the contents of MDA and membrane cholesterol were increased significantly( P 0. 05),and SA had a decreased tendency. Conclusion: Models with stagnation of phlegm and blood can cause the increase of cholesterol,and the plasma viscosity is also increased. It might lead to the decrease of SOD and Na+- K+-ATP enzyme,meanwhile,MDA and membrane cholesterol contents have been changed to different degrees. Meanwhile,the content of SA has a decreased tendency.